Scientist II, Downstream Viral Vector Process Development

Genefab · Alameda, CA

GeneFab is seeking an experienced Downstream Process Development Scientist/Lead focused on viral vector purification (AAV and Lentiviral) for in vivo gene therapy. It is a technical, project-based role within a CRDMO environment that balances hands-on process optimization with cross-functional leadership and client-facing responsibilities.

 

Responsibilities

  • Design, optimize, and scale-up downstream processes for the purification of viral
    vectors, with a focus on in vivo gene therapy products and lentiviral vectors.
  • Execute experimental plans, analyze data, and provide insightful
    recommendations to improve process efficiency, yield, and product quality.
  • Collaborate with cross-functional teams, including Upstream Process
    Development, Analytical Development, and Manufacturing, to ensure seamless
    integration of processes.
  • Troubleshoot and resolve technical challenges in downstream processes, ensuring
    robust and scalable solutions.
  • Present internally and to client with project status updates
  • Stay abreast of industry trends, emerging technologies, and regulatory guidelines
    to contribute to the continuous improvement of processes and compliance.
  • Provide direction and leadership to development associates as the team expands.

    • Qualifications

  • Ph.D. or Master’s degree in Chemical Engineering, Biochemical Engineering,
    Biotechnology, or related field with a minimum of 3 years (Ph.D.) or 5 years
    (Master’s) of relevant industry experience
  • Proven expertise in downstream process development for viral vectors, with a
    focus on AAV and lentiviral vectors.
  • Hands-on experience with chromatography, filtration, TFF and other downstream
    processing techniques.
  • Strong analytical and problem-solving skills, with the ability to interpret complex
    data sets.
  • Excellent communication skills and the ability to work collaboratively in a team
    environment.
  • Knowledge of regulatory requirements and quality standards related to
    biopharmaceutical manufacturing.
  • Experience with formulation science preferred

    • Science & R&D pay context

    Based on 582 disclosed Science & R&D salaries on RoleSuite, the role pays a median of $141K/year, with most offers between $106K and $176K (10th–90th percentile: $84K–$223K).

    This posting lists $130K–$150K, in line with the $141K market median.

    See the full Science & R&D salary breakdown →
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