Senior Clinical Project Manager

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Senior Clinical Project Manager based in the United States.

This role sits at the center of complex, global clinical research programs, ensuring studies are delivered on time, within scope, and in compliance with strict regulatory standards. You will coordinate cross-functional teams spanning clinical operations, data management, biostatistics, regulatory affairs, and vendors to drive seamless study execution from start-up through close-out. The position combines strategic oversight with hands-on project leadership, requiring strong financial acumen, risk management, and stakeholder communication. You will also serve as the key point of contact for sponsors, ensuring alignment on timelines, budgets, and deliverables. Working in a fast-paced, science-driven environment, you will help advance clinical trials that directly contribute to improving patient outcomes worldwide. This is a high-impact role suited for an experienced leader who thrives in global, matrixed clinical research settings.

• Oversee end-to-end management of Phase I–IV clinical trials, ensuring adherence to timelines, budgets, SOPs, and global regulatory requirements (ICH, FDA, EMA, Health Canada).
• Coordinate cross-functional project teams including clinical operations, data management, biostatistics, regulatory, vendors, and medical writing to ensure seamless study execution.
• Develop, maintain, and track detailed project plans, budgets, resource allocations, and risk mitigation strategies using established project management tools and methodologies.
• Act as primary liaison with sponsors, managing communication, scope alignment, contract execution, change orders, and issue resolution.
• Monitor project performance through regular reporting, financial tracking, and milestone updates, escalating risks and deviations proactively.
• Facilitate project meetings, drive decision-making, and ensure timely follow-up on action items across internal and external stakeholders.
• Support RFI/RFP responses, project proposals, and business development opportunities as needed.

Requirements

The ideal candidate brings extensive experience in clinical research project leadership, supported by a life sciences or health-related academic background. You should have deep knowledge of clinical trial processes across phases, strong financial and operational planning skills, and the ability to manage complex global studies in a regulated environment.

• Bachelor’s or Master’s degree in Life Sciences, Health Sciences, or related field.
• 10+ years of clinical research experience, including at least 7 years in clinical project management within a CRO, pharmaceutical, or biotech environment.
• Strong expertise in managing Phase I–IV clinical trials, including oncology experience.
• Solid understanding of ICH guidelines and regulatory frameworks (FDA, EMA, Health Canada).
• Proven ability to lead cross-functional teams and manage multiple stakeholders in a matrixed environment.
• Strong financial acumen, including budgeting, forecasting, and scope/change management.
• Excellent communication, negotiation, and presentation skills with a proactive, solution-oriented mindset.
• Proficiency in project planning tools and structured project management methodologies.

Benefits

• Competitive salary estimated between $125,000 – $175,000 annually
• Performance-based bonus eligibility
• Comprehensive medical, dental, and vision insurance
• Life, AD&D, and disability coverage (short- and long-term)
• 401(k) retirement savings plan
• Generous paid time off and sick leave
• Tuition and fitness reimbursement programs
• Employee assistance program (EAP)
• Opportunity to work on global, high-impact clinical research programs
• Professional growth in a leading clinical research organization